The park lies in north western Uganda, spreading inland from the shore of Lake Albert around the Victoria Nile. Together with the adjacent 748 square kilometers Bugungu Wildlife Reserve and the 720 square kilometers Karuma Wildlife Reserve, the park forms the Murchison Falls Conservation Area MFCA. Kabalega / Murchison Falls National Park is located in Buliisa District in western Uganda and in Nwoya District in northern Uganda. The park is situated approximately 300 kilometers, by road, northwest of Kampala, Uganda’s capital city.
The climate in Murchison Falls is tropical and hot. Being close to the equator, temperatures are quite uniform throughout the year. The area around Murchison Falls National Park (MFNP) has two rainy seasons. These seasons are not as pronounced as they are at more equatorial regions in Uganda.